Molecules

Synthesis and biological evaluation of 3-aryl-quinoxaline-2-carbonitrile 1, 4-di-N-oxide derivatives as hypoxic selective anti-tumor agents

Y Hu, Q Xia, S Shangguan, X Liu, Y Hu, R Sheng

文献索引：Hu, Yunzhen; Xia, Qing; Shangguan, Shihao; Liu, Xiaowen; Hu, Yongzhou; Sheng, Rong Molecules, 2012 , vol. 17, # 8 p. 9683 - 9696

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被引用次数: 15

摘要

Abstract: A series of 3-aryl-2-quinoxaline-carbonitrile 1, 4-di-N-oxide derivatives were designed, synthesized and evaluated for hypoxic and normoxic cytotoxic activity against human SMMC-7721, K562, KB, A549 and PC-3 cell lines. Many of these new compounds displayed more potent hypoxic cytotoxic activity compared with TX-402 and TPZ in the tumor cells based evaluation, which confirmed our hypothesis that the replacement of the 3- ...