Tetrahedron Letters

Application of iron carbonyl complexation to the selective total synthesis of sanshools

K Aoki, Y Igarashi, H Nishimura, I Morishita, K Usui

文献索引：Aoki, Katsuyuki; Igarashi, Yasushi; Nishimura, Hiroaki; Morishita, Isao; Usui, Kimitoshi Tetrahedron Letters, 2012 , vol. 53, # 45 p. 6000 - 6003

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被引用次数: 3

摘要

We focused on the iron-complexes of sanshools (hydroxyl-α-sanshool, hydroxyl-β-sanshool, and γ-sanshool) as the key intermediates for the selective synthesis of these structurally unstable compounds. Consequently, we developed a concise and selective method for the total synthesis of sanshools in 5–6 steps (26–45% overall yield), including complexation of dienes with iron tricarbonyl group.