Synthesis of the N??oxides of phenothiazine antipsychotic agents

TJ Jaworski, MS Sardessai, M Aravagiri…

文献索引：Jaworski; Sardessai; Aravagiri; Lin; Shi; Hawes; Hubbard; McKay; Midha Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 3 p. 330 - 333

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被引用次数: 9

摘要

Abstract Chlorpromazine N-oxide, fluphenazine N4′-oxide, prochlor-perazine N 4′-oxide, sulforidazine N-oxide, and trifluoperazine N 4′-oxide were synthesized by oxidation of the designated nitrogen atom in the N-10 side chain of the respective parent drug with 3- chloroperoxybenzoic acid. In the case of trifluoperazine, a stepwise increase in the amount of oxidant yielded the N 1′, N 4′-dioxide and N 1′, N 4′, S-trioxide. The N′, S- ...