Tetrahedron

Stereoselective Synthesis of cis-Bis-β-lactams Linked with an Ethylene Bridge

K Karupaiyan, VG Puranik, A Deshmukh, BM Bhawal

文献索引：Karupaiyan; Puranik; Deshmukh; Bhawal Tetrahedron, 2000 , vol. 56, # 43 p. 8555 - 8560

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被引用次数: 32

摘要

Although β-lactam derivatives are well known for their antibiotic activities, 1 recently they have also been used as a synthon for the synthesis of various natural and unnatural products. 2 Ojima has shown the utility of bis-β-lactams for the synthesis 3 of peptides. The synthesis of bis-β-lactams, in general, have been reported by step-wise construction of β-lactam rings. 4 In continuation of our work on synthesis of bis-β-lactams, 4. and 5. we were interested in ...