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5-N-Substituted-2-(substituted benzenesulphonyl) glutamines as antitumor agents. Part II: Synthesis, biological activity and QSAR study

S Samanta, K Srikanth, S Banerjee, B Debnath…

文献索引:Samanta, Soma; Srikanth; Banerjee, Suchandra; Debnath, Bikash; Gayen, Shovanlal; Jha, Tarun Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1413 - 1423

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被引用次数: 46

摘要

Cancer is a major killer disease throughout human history. Thus, cancer becomes a major point of interest in life science. It was proved that cancer is a nitrogen trap and tumor cells are avid glutamine consumers. The non-essential amino acid glutamine, which is a glutamic acid derivative, supplies its amide nitrogen to tumor cells in the biosynthesis of purine and pyrimidine bases of nucleic acids as well as takes part in protein synthesis. Based on ...