Potential anxiolytic agents. Pyrido [1, 2-a] benzimidazoles: A new structural class of ligands for the benzodiazepine binding site on GABA-A receptors

BE Maryanoff, W Ho, DF McComsey…

文献索引：Maryanoff, Bruce E.; Ho, Winston; McComsey, David F.; Reitz, Allen B.; Grous, Philip P.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 1 p. 16 - 20

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被引用次数: 57

摘要

Receptors for y-aminobutyric acid of the “A” variety (GABA-A receptors), the most abundant inhibitory receptors in mammalian brain, are structurally constituted as macromolecular heteropentameric assemblies (combinations of a,/I, and $6 protein subunits). l Each GABA-A receptor complex comprises a chloride ion channel that not only controls chloride flux across neuronal membranes, but also bears multiple recognition sites for small modulatory ...