Bioorganic & medicinal chemistry

Antitumor studies. Part 4: Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides …

HI Ali, N Ashida, T Nagamatsu

文献索引：Ali, Hamed I.; Ashida, Noriyuki; Nagamatsu, Tomohisa Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 2 p. 922 - 940

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被引用次数: 31

摘要

Various novel 10-alkyl-2-deoxo-2-methylthioflavin-5-oxides and their 2-alkylamino derivatives were prepared by facile nitrosative cyclization of 6-(N-alkylanilino)-2- methylthiopyrimidin-4 (3H)-ones followed by nucleophilic replacement of the 2-methylthio moiety by different amines, and acidic hydrolysis of the 2-methylthio moiety afforded the corresponding flavin derivatives. 2-Deoxo-2-methylthio-5-deazaalloxazines and 2-deoxo- ...