The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines

…, CH Chui, R Gambari, MCW Yuen, RSM Wong…

文献索引：Chan, Sau Hing; Lam, Kim Hung; Chui, Chung Hin; Gambari, Roberto; Yuen, Marcus Chun Wah; Wong, Raymond Siu Ming; Cheng, Gregory Yin Ming; Lau, Fung Yi; Au, Yiu Kwok; Cheng, Chor Hing; Lai, Paul Bo Shan; Kan, Chi Wai; Kok, Stanton Hon Lung; Tang, Johnny Cheuk On; Chan, Albert Sun Chi European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2736 - 2740

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被引用次数: 19

摘要

The 'one pot'condensation reaction for the synthesis and potent antiproliferative inhibition of α-phthalimide based ketones is reported here. 2-Phthalimide-1-(4-fluoro-phenyl) ethanone (5) showed the best growth inhibition on human MDAMB-231 breast carcinoma and SKHep- 1 hepatoma cell lines. Preliminary studies showed that the reported bioactivity may be due to the presence of strong electronegative fluorine group at the para-position of the aryl ring.