Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48

…, D Joseph-McCarthy, BC Follows, YL Zhang

文献索引：Wan, Zhao-Kui; Lee, Jinbo; Xu, Weixin; Erbe, David V.; Joseph-McCarthy, Diane; Follows, Bruce C.; Zhang, Yan-Ling Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4941 - 4945

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被引用次数: 50

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B. ... A series of monocyclic ...