A novel class of conformationally restricted heterocyclic muscarinic agonists

…, JJ Larsen, E Falch, P Krogsgaard-Larsen

文献索引：Sauerberg; Larsen; Falch; Krogsgaard-Larsen Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1004 - 1009

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被引用次数: 29

摘要

A sed of conformationally restricted compounds containing the 4, 5, 6, 7-tetrahydroi0 [4, 5-c] pyridin-3-01 (THPO) skeleton, including 0-methyl-THPO (loa) and 0, 5-dimethyl-THPO (1 la), were synthesized. The compounds were designed by bioisosteric replacement of the methyl ester groups of the muscarinic cholinergic agonists norarecoline and arecoline by the 3- methoxyisoxazole group, and their interactions with central and peripheral muscarinic ...