Methodology for the synthesis of the spiro [4.4] nonane system: an approach for the total synthesis of fredericamycin A

AVR Rao, DR Reddy, VH Deshpande

文献索引：Rao, A. V. Rama; Reddy, D. Reddeppa; Deshpande, V. H. Journal of the Chemical Society, Chemical Communications, 1984 , # 16 p. 1119 - 1120

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摘要

A convenient approach for building the spiro[4.4]nonane system present in fredericamycin A, an antitumour anti biotic, is described and the X-ray crystal structure presented. ... Fredericamycin A (1),1 an antitumour antibiotic produced by Streptomyces griseus, possesses an entirely novel spiro[4.4]no- nane system which has not been observed in any other types of antibiotics. It has certain interesting spacial characteristics (the two aromatic portions are nearly at right ...