The Journal of Organic Chemistry

Heterocyclic deformations from molecular enlargement

JB Lambert, SM Wharry

文献索引：Lambert, Joseph B.; Wharry, Stephen M. Journal of Organic Chemistry, 1982 , vol. 47, # 20 p. 3890 - 3893

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被引用次数: 10

摘要

The ease of distortion of saturated nitrogen heterocycles has been examined by progressively increasing the bulk of the substituent at nitrogen. The heterocycles included the pharmacophoric piperidine and morpholine six-membered rings, as well as the five- membered oxazolidine ring. Response to increased bulk of substitution was intended to be a crude model for distortions within the drug-receptor complex. Substitution at nitrogen ...