Heterocycles

Studies with plant cell cultures of Podophyllum peltatum L. II: Biotransformation of dibenzylbutanolides to lignans. Development of a biological factory'for lignan …

…, YP Chen, GAO SHIXIAN, GM Hewitt, F Kuri-Brena…

文献索引：Kutney, James P.; Chen, Yung Ping; Gao, Shixiang; Hewitt, Gary M.; Kuri-Brena, Francisco; et al. Heterocycles, 1993 , vol. 36, # 1 p. 13 - 20

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被引用次数: 16

摘要

Résumé/Abstract An efficient and versatile synthetic route to appropriate dibenzylbutanolides suitable for biotransformation to lignans as potential intermediates for the syntheses of the clinical anti-cancer drug etoposide has been developed. Biotransformation of such substrates, for example 10, with cell cultures of Podophyllum peltatum affords a potentially exciting route to this drug. Of particular significance is the ...