“Molecular Chameleons”. Design and Synthesis of a Second Series of Flexible Nucleosides

…, S Salim, L Zhang, PI O'Daniel

文献索引：Seley, Katherine L.; Salim, Samer; Zhang, Liang; O'Daniel, Peter I. Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1612 - 1619

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被引用次数: 39

摘要

The second series of flexible shape-modified nucleosides is introduced. The “fleximers” feature the purine ring systems split into their individual imidazole and pyrimidine components. This structural modification serves to introduce flexibility to the nucleoside while still retaining the elements essential for recognition. As a consequence, these structurally innovative nucleosides can more readily adapt to their environment and ...