Synthesis and transfection efficiencies of new lipophilic polyamines

…, M Belting, K Svensson, O Phanstiel IV

文献索引：Gardner, Richard Andrew; Belting, Mattias; Svensson, Katrin; Phanstiel IV, Otto Journal of Medicinal Chemistry, 2007 , vol. 50, # 2 p. 308 - 318

全文：HTML全文

被引用次数: 30

摘要

A homologous series of lipophilic polyamines was synthesized and evaluated for DNA delivery and transfection efficiency. The series contained 1, 4-butanediamine, 1, 8- octanediamine, 2-[2-(2-amino-ethoxy)-ethoxy]-ethylamine, homospermidine, and homospermine covalently attached via their N 1 terminus to a 3, 4-bis (oleyloxy)-benzyl motif. In addition, homospermidine and homospermine were also attached via amide ...