Cyclopentadienyl-Based Amino Acids (Cp-aa) As Phenylalanine Analogues for Tumor Targeting: Syntheses and Biological Properties of [(Cp-aa) M (CO) 3](M= Mn, …

…, P Schmutz, M Bauwens, B Spingler, R Alberto

文献索引：Liu, Yu; Pak, Jae Kyoung; Schmutz, Paul; Bauwens, Matthias; Mertens, John; Knight, Hector; Alberto, Roger Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15996 - 15997

全文：HTML全文

被引用次数: 10

摘要

Due to an enhanced demand for amino acids, the l-type amino acid transporter 1 (LAT1) is overexpressed in many tumor cell lines. LAT1 represents therefore an attractive target for cancer therapy and diagnosis. On the basis of our reported aqueous synthesis of [(Cp-R) 99mTc (CO) 3]-type complexes,(1-5) we describe the preparation of unnatural amino acid analogues [(Cp-CH2CH (NH2) COOH) Mn (CO) 3] and [(Cp-CH (NH2) COOH) M (CO) 3]( ...