Synthesis and pharmacological activity of N-substituted derivatives of 9-(3-amino-2-hydroxypropyl) carbazoles

…, AT Dolzhenko, RE Kononova, OV Charfas…

文献索引：Mysyk, D. D.; Dolzhenko, A. T.; Kononova, R. E.; Charfas, O. V.; Galat, V. F. Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 4 p. 266 - 268 Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 4 p. 449 - 451

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摘要

Diethylamine, piperidine, hexamethylenediimine, and morpholine are added to 9-(2, 3- epoxypropyl) carbazole (I), when the components are heated in boiling ethanol. The oxirane ring is opened with cleavage of the CO bond at the primary atom, which corresponds to the direction of opening of the oxirane ring in the nucleophilic addition of the carbazolyl anion to I [2] and was confirmed by the study of compounds ll-V by NMR spectroscopy.