Efficient synthesis of functionalized furans via ruthenium-catalyzed cyclization of epoxyalkyne derivatives

…, H Guo, JJ Lian, FM Shen, RS Liu

文献索引：Lo, Ching-Yu; Guo, Hongyun; Lian, Jian-Jou; Shen, Fwu-Ming; Liu, Rai-Shung Journal of Organic Chemistry, 2002 , vol. 67, # 11 p. 3930 - 3932

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被引用次数: 65

摘要

Ruthenium catalyst TpRuPPh3 (CH3CN) 2Cl is found to effect the cyclization of epoxyalkynes to furans in the presence of Et3N. The reactions worked well for various epoxyalkynes with suitable oxygen and nitrogen functionalities with low loading of catalyst. It failed with disubstituted epoxyalkynes. The mechanism was elucidated by a deuterium labeling experiment that suggested that the mechanism involved a ruthenium- ...