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Total synthesis of vineomycin B2 aglycon

S Danishefsky, BJ Uang, G Quallich

文献索引:Danishefsky, Samuel J.; Uang, Biing Jium; Quallich, George Journal of the American Chemical Society, 1984 , vol. 106, # 8 p. 2453 - 2455

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被引用次数: 36

摘要

Attempted reactions of 16 wiht several acetic acid dianon equivalents were unsuccessful, possibly due to competing reactions from the quinone. Accordingly, 16 was converted to 1719 as shown. AnalogyZo suggested that a metal phenoxide species (generated in situ) might be less vulnerable to nucleophilic attack by external enolates.