Identification of aminopyridazine-derived antineuroinflammatory agents effective in an Alzheimer's mouse model

W Zhou, G Zhong, X Rao, H Xie, S Zeng…

文献索引：Zhou, Wei; Zhong, Guifa; Rao, Xiurong; Xie, Hui; Zeng, Shaogao; Chi, Tianyan; Zou, Libo; Wu, Donghai; Hu, Wenhui ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 11 p. 903 - 907

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被引用次数: 7

摘要

Targeting neuroinflammation may be a new strategy to combat Alzheimer's disease. An aminopyridazine 1b previously reported as a novel antineuroinflammatory agent was considered to have a potential therapeutic effect for Alzheimer's disease. In this study, we further explored the chemical space to identify more potent antineuroinflammatory agents and validate their in vivo efficacy in an animal model. Compound 14 was finally identified ...