Kynurenic acid derivatives inhibit the binding of nerve growth factor (NGF) to the low-affinity p75 NGF receptor

…, BW Caprathe, RJ Sorenson, J Fergus…

文献索引：Jaen; Laborde; Bucsh; Caprathe; Sorenson; Fergus; Spiegel; Marks; Dickerson; Davis Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4439 - 4445

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被引用次数: 34

摘要

The ability of a series of substituted kynurenic acids, thienopyridinonecarboxylic acids, and related compounds to inhibit the binding of nerve growth factor (NGF) to the p75 NGF receptor (KGFR) was evaluated in a radioligand binding assay that utilized a biotinylated derivative of the extracellular domain of p75 NGFR (p75, J fixed to streptavidin-coated plastic wells. Two compounds, 6-aminokynurenic acid (5hj and the 3-methyl ester of 4, 7- ...