Abstract The Knoevenagel reactions of malononitrile with acetophenone or 4-substituted acetophenons were carried to give the corresponding 2-(1-aryle thylidene) malononitriles, which was further cyclized with sulfur using NaHCO 3 as catalysts to generate 2-amino-5- arylthiophene-3-carbonitrile 2. The intermediate enamines 3 were prepared by refluxing of 2 with 5-substituted-1, 3-cyclohexanedione using p-toluenesulfonic acid as catalyst. The title ...
