Synthesis of new 3-aryl-4, 5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase

E Maccioni, S Alcaro, F Orallo, MC Cardia…

文献索引：MacCioni; Alcaro; Orallo; Cardia; Distinto; Costa; Yanez; Sanna; Vigo; Meleddu; Secci European Journal of Medicinal Chemistry, 2010 , vol. 45, # 10 p. 4490 - 4498

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被引用次数: 26

摘要

Some differently substituted 3-aryl-4, 5-dihydropyrazoles-1-carbothioamides have been synthesised with the aim to investigate their monoamine oxidase inhibitory activity. The chemical structures of the compounds have been characterized by means of their IR, 1H NMR, 13C NMR spectroscopic data and elemental analyses. All the active compounds showed a selective activity towards the B isoform of the enzyme, regardless of the ...