The Journal of Organic Chemistry

Synthesis of a new photolabile support. 4-(2-Chloropropionyl) phenylacetamidomethyl-resin and its application in solid-phase peptide synthesis

FS Tjoeng, GA Heavner

文献索引：Tjoeng, Foe-Siong; Heavner, George A. Journal of Organic Chemistry, 1983 , vol. 48, # 3 p. 355 - 359

全文：HTML全文

被引用次数: 34

摘要

The preparation of a new photolabile resin for solid-phase peptide synthesis is described.[4- (2-Chloropropionyl) phenyl] acetic acid was used as the handle and was obtained in three steps with an 82% overall yield on starting from phenylacetic acid. The incorporation of the handle to the aminomethyl-resin to form 4-(2-chloropropiony1) phenylacetamidomethyLresin was achieved via its acid chloride or ...