Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity
…, RR Harris, RJ Collins, RL Corbett…
文献索引：Wright, Stephen W.; Harris, Richard R.; Collins, Robert J.; Corbett, Ronald L.; Green, Alicia M.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3148 - 3155
A variety of inflammatory skin diseases are characterized by increased levels of proinflammatory arachidonic acid metabolites. These metabolites include those derived from the 5-lipoxygenase (5-LO) and 12-lipoxygenase (12-LO) pathway.'Conventional non- steroidal antiinflammatory drugs, such as indomethacin, inhibit cyclooxygenase (CO) and the biosynthesis of prostaglandins and thromboxanes but do not improve the condition of ...
