A novel facile synthesis of carbamoylmethylphosphine oxides in ionic liquids

…, OI Artyushin, AS Shaplov, GV Myasoedova…

文献索引：Sharova, Elena V.; Artyushin, Oleg I.; Shaplov, Alexander S.; Myasoedova, Galina V.; Odinets, Irina L. Tetrahedron Letters, 2008 , vol. 49, # 10 p. 1641 - 1644

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被引用次数: 12

摘要

A convenient access to carbamoylmethylphosphine oxides (CMPO) in up to 96% isolated yield is developed via direct amidation of diphenylphosphoryl acetic acid in an ionic liquid as a recyclable reaction medium in the presence of triphenyl phosphite. The influence of the nature of the amine and anion and cation structure in the ionic liquid on the reaction rate and yields of the products are also investigated. 1-Butyl-3-methylimidazolium bromide [bmim] ...