Development of novel 4-aminopyridine derivatives as potential treatments for neurological injury and disease

…, R Shi, RB Borgens, JM McBride, K Jackson…

文献索引：Smith, Daniel T.; Shi, Riyi; Borgens, Richard B.; McBride, Jennifer M.; Jackson, Kevin; Byrn, Stephen R. European Journal of Medicinal Chemistry, 2005 , vol. 40, # 9 p. 908 - 917

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被引用次数: 28

摘要

The amine position of the K+ channel blocker 4-aminopyridine was functionalized to form amide, carbamate and urea derivatives in an attempt to identify novel compounds which restore conduction in injured spinal cord. Eight derivatives were tested in vitro, using a double sucrose gap chamber, for the ability to restore conduction in isolated, injured guinea pig spinal cord. The methyl, ethyl and t-butyl carbamates of 4-aminopyridine induced an ...