The protection of alcoholic hydroxyl groups has found application especially in the synthesis of natural products related to terpenes, steroids, sugars, and glycerids. Tetrahydropyranylation is one of the frequently used methods for the protection of alcohols and phenols because of the remarkable stability towards a variety of conditions such as reactions involving Grignard reagents and lithium alkyl and reduction with hydrides, alkylating, and acylating agents. [ 1 1. ...