Chemical communications

The direct α-zincation of amides, phosphonates and phosphine oxides by H–Zn exchange

ML Hlavinka, JF Greco, JR Hagadorn

文献索引：Hlavinka, Mark L.; Greco, Jeffrey F.; Hagadorn, John R. Chemical Communications, 2005 , # 42 p. 5304 - 5306

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摘要

Functionalized organozincs are frequently used as C-nucleophiles in the synthesis of complex organic molecules. 1 Due to their low basicities they tolerate a wide range of sensitive functional groups, yet they react with many electrophiles and readily undergo transmetalation reactions with transition-metal salts. Thus, they are indispensable intermediates in many C–C bond-forming reactions, 2 particularly those mediated by Cu and Pd complexes. 3 The preparation of ...