Metabolism of the nigrostriatal toxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine by liver homogenate fractions

…, LA Peterson, P Caldera, N Castagnoli Jr…

文献索引：Weissman; Trevor; Chiba; Peterson; Caldera; Castagnoli Jr.; Baillie Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 997 - 1001

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被引用次数: 81

摘要

The metabolic fate of the nigrostriatal toxin l-methyl-4pheny1-1, 2, 3, 6-tetrahydropyridine (MPTP) has been examined in rat and rabbit liver mitochondrial and rabbit liver microsomal preparations. The mitochondrial preparations rapidly oxidized MPTP, in a pargyline- sensitive reaction, to a polar material that was shown to contain the 1-methyl-4- phenylpyridinium species as the principal product. NADPH-supplemented microsomal ...