Synthesis of 1-[ω-(benzhydrylpiperazin-1-yl) alkyl] indoles, 9-[3-(4-benzhydrylpiperazin-1-yl) propyl) carbazole and its derivatives and their antiallergic activity
NA Komissarenko, VP Gorbunova, VB Nikitin…
文献索引：Komissarenko, N. A.; Gorbunova, V. P.; Nikitin, V. B.; Kaminka, M. E.; Suvorov, N. N. Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 10 p. 751 - 754 Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 10 p. 54 - 56
According to scheme A, 1-(3-chloropropyl)-4-benzhydrylpiperazine (III) was obtained by alkylation of lbenzhydrylpiperazine [2, 3, 12](I) by l-bromo-3-chloropropane [5](II). 1-[3-(4- Benzhydrylpiperazin-1-yl) propyl] indole (V) and 9-[3-(4-benzhydrylpiperazin-l-yl) propyl]-4- oxo-l, 2, 3, 4-tetrahydrocarbazole (VI) were obtained by alkylation of indole (IV) and 4-oxo-l, 2, 3, 4-tetrahydrocarbazole [9, I0, 11], respectively, by compound III, using the method of ...
