Synthesis and antifertility activity of 3, 9-dihydroxy-5, 6, 6a. alpha., 6b. beta., 11, 12, 12a. beta., 12b. alpha.-octahydrodibenzo [a, g] biphenylene, a structural relative of …

…, EH Vickery, NR Beller, EJ Eisenbraun…

文献索引：Ruehle; Browne; Vickery; Beller; Eisenbraun; Loghry; Van der Helm Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1410 - 1414

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被引用次数: 4

摘要

2 3 benzo [ag] biphenylene (la) to diethylstilbestrol (2, DES) and estradiol (3)(Chart I) encouraged us to develop a stereospecific synthesis of la to determine if structures of this type would provide significant postcoital antifertility activity with reduced estrogenic activity. Although estrogenicity generally parallels antifertility activity, some success has been achieved in separating these effe~ ts.~ Chemistry. The synthesis of diphenol la is shown ...