Tetrahedron

Synthesis of oligodeoxynucleotides and oligodeoxynucleotide analogs using phosphoramidite intermediates

MA Dorman, SA Noble, LJ McBride, MH Caruthers

文献索引：Dorman, M.A.; Noble, S.A.; McBride, L.J.; Caruthers, M.H. Tetrahedron, 1984 , vol. 40, # 1 p. 95 - 102

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被引用次数: 95

摘要

The synthesis of two deoxyoligonucleotides, d (GTGAGTTAGCTCAC) and d (GTGAGCTAACTCAC), corresponding to the DNA binding site for cyclic AMP receptor protein is reported. These syntheses have been completed in milligram quantities using a silica gel polymer support methodology and mononucleotide phosphoramidites. Procedures are also reported for synthesizing diastereoisomers of dinucleoside methylphosphonate 3 ...