Mutagenesis

Protection against Trp-P-2 mutagenicity by purpurin: mechanism of in vitro antimutagenesis

T Marczylo, S Arimoto-Kobayashi, H Hayatsu

文献索引：Marczylo, Tim; Arimoto-Kobayashi, Sakae; Hayatsu, Hikoya Mutagenesis, 2000 , vol. 15, # 3 p. 223 - 228

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被引用次数: 26

摘要

Abstract Purpurin (1, 2, 4-trihydroxy-9, 10-anthraquinone) is a natural pigment isolated from madder root (Rubia tinctorum) which inhibits the mutagenicity of a number of heterocyclic amines in the Ames mutagenicity test. Two effects were observed in the presence of purpurin. The rate of degradation of 3-hydroxyamino-1-methyl-5H-pyrido [4, 3-b] indole [Trp- P-2 (NHOH)] at neutral pH was increased. The major product of this purpurin-dependent ...