Canadian Journal of Chemistry

Thiazoloisoquinolines. IV. The Synthesis and Spectra of Thiazolo [4, 5-h]-and Thiazolo [5, 4-f] isoquinolines. The Ultraviolet and Proton Magnetic Resonance Spectra …

A Taurins, RKC Hsia

文献索引：Taurins,A.; Hsia,R.K.-C. Canadian Journal of Chemistry, 1971 , vol. 49, p. 4054 - 4064

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被引用次数: 12

摘要

Thiazolo [4, 5-h] isoquinoline was synthesized from 7-aminoisoquinoline in four steps: by the reaction with potassium thiocyanate and bromine to give 7-amino-8-thiocyanoisoquinoline; cyclization of the latter with hydrochloric acid to produce 2-aminothiazolo [4, 5-h] isoquinoline, followed by the Sandmeyer reaction to yield a 2-chloro derivative, and finally, reduction with hydriodic acid and phosphorus. Thiazolo [5, 4-f] isoquinoline was prepared ...