Tetrahedron: Asymmetry

Efficient enantioselective synthesis of (2R, 3R)-and (2S, 3S)-3-hydroxyleucines and their diastereomers through dynamic kinetic resolution

K Makino, N Okamoto, O Hara, Y Hamada

文献索引：Makino, Kazuishi; Okamoto, Naoki; Hara, Osamu; Hamada, Yasumasa Tetrahedron Asymmetry, 2001 , vol. 12, # 12 p. 1757 - 1762

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被引用次数: 61

摘要

(2R, 3R)-and (2S, 3S)-3-Hydroxyleucines, components of cyclodepsipeptides, papuamides and polyoxypeptins, were efficiently synthesized along with their diastereomers from the corresponding β-keto-α-amino acid ester through dynamic kinetic resolution using RuCl2 (binap)-catalyzed hydrogenation.