The Synthesis and γ-Aminobutyric Acid Transaminase Inhibition of Aminoöxy Acids and Related Compounds

EL Schumann, LA Paquette…

文献索引：Schumann,E.L. et al. Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 464 - 477

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被引用次数: 22

摘要

A series of forty-six aminooxy derivatives and thirty-six analogs of 7-aminobutyric acid was prepared and tested for inhibition of yaminobutyric acid transaminase and for protection against thiosemicarbazide-induced convulsions. Good in vivo activity in these tests was generally limited to certain a-aminooxyacids or their easily hydrolyzed derivatives, such as esters. None of the compounds studied was superior to aminooxyacetic acid.