Depigmenting activity and low cytotoxicity of alkoxy benzoates or alkoxy cinnamte in cultured melanocytes

HH Kang, HS Rho, JS Hwang, SG Oh

文献索引：Kang, Hak Hee; Rho, Ho Sik; Hwang, Jae Sung; Oh, Seong-Geon Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 9 p. 1085 - 1088

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被引用次数: 20

摘要

To obtain effective and safe topical depigmenting agents, we synthesized hydroxybenzoates, alkoxybenzoates, and 3, 4, 5-trimethoxycinnamate containing a thymol moiety and screened then for high-level inhibitory activity against melanin synthesis in cultured melanocytes. Eight compounds were tested for their depigmenting effect and cytotoxicity using a murine melanocyte cell line. We found that 3, 4, 5-trialkoxybenzoates ...