Synthesis, antifungal activity and CoMFA analysis of novel 1, 2, 4-triazolo [1, 5-a] pyrimidine derivatives

Q Chen, XL Zhu, LL Jiang, ZM Liu, GF Yang

文献索引：Chen, Qiong; Zhu, Xiao-Lei; Jiang, Li-Li; Liu, Zu-Ming; Yang, Guang-Fu European Journal of Medicinal Chemistry, 2008 , vol. 43, # 3 p. 595 - 603

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被引用次数: 162

摘要

In order to search novel agrochemicals with higher antifungal activity, a series of new 1, 2, 4- triazolo [1, 5-a] pyrimidine derivatives bearing 1, 3, 4-oxadiazole moieties were designed and synthesized. Their antifungal activities against Rhizoctonia solani were evaluated in vitro. By determining the EC50 values of all the newly synthesized compounds and 10 formerly synthesized compounds, compound 8r, 2-((5-(sec-butylthio)-1, 3, 4-oxadiazol-2-yl ...