The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits

…, K Herry, A Hobbs, CI Hobbs, P Homes…

文献索引：Tominaga, Yoshinori; Matsuoka, Yoshiki; Kohra, Shinya; Hosomi, Akira Heterocycles, 1987 , vol. 26, # 3 p. 613 - 616

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被引用次数: 7

摘要

... Volume: Page: ... fragment and high throughput screens, enabled the discovery of the first series of potent inhibitors of mitochondrial branched-chain aminotransferase (BCATm) based on a 2-benzylamino-pyrazolo[1,5-a]pyrimidinone-3-carbonitrile template. ...