Fluorescence of cis-1-Amino-2-(3-indolyl) cyclohexane-1-carboxylic Acid: A Single Tryptophan ξ1 Rotamer Model

…, PD Adams, FR Fronczek, ML McLaughlin…

文献索引：Liu, Bo; Thalji, Reema K.; Adams, Paul D.; Fronczek, Frank R.; McLaughlin, Mark L.; Barkley, Mary D. Journal of the American Chemical Society, 2002 , vol. 124, # 44 p. 13329 - 13338

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被引用次数: 23

摘要

A constrained derivative, cis-1-amino-2-(3-indolyl) cyclohexane-1-carboxylic acid, cis-W3, was designed to test the rotamer model of tryptophan photophysics. The conformational constraint enforces a single ξ1 conformation, analogous to the ξ1= 60° rotamer of tryptophan. The side-chain torsion angles in the X-ray structure of cis-W3 were ξ1= 58.5° and ξ2=-88.7°. Molecular mechanics calculations suggested two ξ2 rotamers for cis-W3 in ...