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Influence of the Double??Bond Geometry of the Michael Acceptor on Copper??Catalyzed Asymmetric Conjugate Addition

M Vuagnoux??d'Augustin…

文献索引:Vuagnoux-D'Augustin, Magali; Alexakis, Alexandre European Journal of Organic Chemistry, 2007 , # 35 p. 5852 - 5860

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被引用次数: 16

摘要

Abstract Focusing on mechanistic aspects, a study of the influence of the (E)/(Z) double- bond geometry of the Michael acceptor on the enantioselectivity of copper-catalyzed asymmetric conjugate addition reactions has been realized. In spite of numerous articles concerning copper-catalyzed asymmetric conjugate addition reactions, the major factors of such a reaction are quite difficult to elucidate. Although our experiments have not allowed ...