Tetrahedron letters

Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-D-mannosyl phosphate transferase

VS Borodkin, MAJ Ferguson, AV Nikolaev

文献索引：Borodkin, Vladimir S.; Ferguson, Michael A. J.; Nikolaev, Andrei V. Tetrahedron Letters, 2004 , vol. 45, # 4 p. 857 - 862

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被引用次数: 12

摘要

Synthesis of a potential mechanism-based bisubstrate inhibitor of the elongating α-d- mannosyl phosphate transferase in Leishmania, comprising a guanosine subunit bound to the synthetic acceptor substrate through the methylenebisphosphonate linker, as well as its analogues and has been successfully accomplished.