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Antiestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo [b] thiophene derivatives leading to [6-hydroxy-2-(4-hydroxyphenyl) benzo [b] thien-3-yl]-[4 …

CD Jones, MG Jevnikar, AJ Pike…

文献索引:Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066

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被引用次数: 350

摘要

In an effort to prepare nonsteroidal antiestrogens demonstrating greater antagonism and less intrinsic estrogenicity than those currently available, a series of 3-aroyl-2-arylbenzo [b] thiophene derivatives was synthesized. These compounds were prepared by Friedel-Crafts aroylation of appropriate 0-protected 2-arylbenzo [blthiophene nuclei with basic side-chain- bearing benzoyl chlorides followed by removal of the protective groups to provide the ...

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