Steroids

Improved synthesis of unique estradiol-linked platinum (II) complexes showing potent cytocidal activity and affinity for the estrogen receptor alpha and beta

…, V Leblanc, G Bélanger, S Parent, É Asselin, G Bérubé

文献索引：Descoteaux, Caroline; Leblanc, Valerie; Belanger, Geoffroy; Parent, Sophie; Asselin, Eric; Berube, Gervais Steroids, 2008 , vol. 73, # 11 p. 1077 - 1089

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被引用次数: 35

摘要

We have recently reported the synthesis of a platinum (II) complex, made of estradiol, the female sex hormone, and a cisplatin analog, an anticancer drug, linked together by an eleven carbon atoms chain. The novel estradiol-Pt (II) hybrid molecule was synthesized in nine chemical steps with 10% overall yield. This new compound has been tested in vitro on estrogen-dependent (MCF-7) and-independent (MDA-MD-231)(ER+ and ER−) cell lines. ...