(2 R)-4-Oxo-4-[3-(trifluoromethyl)-5, 6-dihydro [1, 2, 4] triazolo [4, 3-a] pyrazin-7 (8 H)-yl]-1-(2, 4, 5-trifluorophenyl) butan-2-amine: a potent, orally active dipeptidyl …

D Kim, L Wang, M Beconi, GJ Eiermann…

文献索引：Journal of Medicinal Chemistry, , vol. 48, # 1 p. 141 - 151

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被引用次数: 689

摘要

... Journal of Medicinal Chemistry. ... development. 11 figure Chart 1. Chemistry. The β-amino acid-derived DPP-IV inhibitors in this report were synthesized by standard peptide coupling of β-amino acids with fused heterocycles. 12 ...