Pyrazole CCK 1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free–Wilson additivity

…, L Li, TD Barrett, N Shankley, JG Breitenbucher

文献索引：Sehon, Clark; McClure, Kelly; Hack, Michael; Morton, Magda; Gomez, Laurent; Li, Lina; Barrett, Terrance D.; Shankley, Nigel; Breitenbucher, J. Guy Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 77 - 80

全文：HTML全文

被引用次数: 21

摘要

High-throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Here, we disclose the synthesis of combinatorial libraries by solid-phase synthesis on Kenner 'safety catch'resin. Additive QSAR models were used to determine a lack of consistent additive SAR within the matrix.