Tetrahedron Letters

First enantioselective synthesis of methyl (+)-7-methoxyanodendroate, an antitubercular dihydrobenzofuran

KM Aumann, NL Hungerford, MJ Coster

文献索引：Aumann, Kylee M.; Hungerford, Natasha L.; Coster, Mark J. Tetrahedron Letters, 2011 , vol. 52, # 51 p. 6988 - 6990

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被引用次数: 8

摘要

The chiral 2-substituted 2,3-dihydrobenzofuran structure is present in a number of biologically important compounds and new enantioselective routes to these systems have recently been described. 4, 5, 6 and 7 Herein, our interest 5 and 8 in dihydrobenzofuran synthesis continues, and we report the first enantioselective synthesis of 1, confirming the absolute configuration as methyl (+)-(S)-7-methoxyanodendroate. ... Our retrosynthetic analysis (Scheme 1) ...