The Journal of Organic Chemistry

Antibiotic X-14547A: total synthesis of the right-hand half

WR Roush, AG Myers

文献索引：Roush, William R.; Myers, Andrew G. Journal of Organic Chemistry, 1981 , vol. 46, # 7 p. 1509 - 1511

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被引用次数: 42

摘要

Summary: A nine-step, stereoselective synthesis of 3, the right-hand half of antibiotic X- 14547A (11, is described. The key step of this synthesis is the Lewis acid catalyzed intramolecular Diels-Alder reaction of 4 which establishes the relative stereochemistry of the perhydroindene nucleus of 1.