Imidazolylchromanones containing non-benzylic oxime ethers: Synthesis and molecular modeling study of new azole antifungals selective against Cryptococcus gattii
M Babazadeh-Qazijahani, H Badali, H Irannejad…
文献索引：Babazadeh-Qazijahani, Mojtaba; Badali, Hamid; Irannejad, Hamid; Afsarian, Mohammad Hosein; Emami, Saeed European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 264 - 273
Abstract A series of imidazolylchromanone oximes containing phenoxyethyl ether moiety, as found in omoconazole, were synthesized and evaluated against yeasts (Candida albicans and Cryptococcus gattii) and filamentous fungi (Aspergillus fumigatus and Exophiala dermatitidis). Although the title compounds showed marginal activity against filamentous fungi but all of them exhibited potent activity against C. gattii (MIC values≤ 4 μg/mL). ...
